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Creator:	Kočović, David
Title:	Synthesis, physicochemical characterization and potential biological activity of new pyrazole and amoxicillin complex compounds
Copyright date:	2025
Trajni link:	https://phaidra.ucg.ac.me/detail_object/o:1936?tab=0#mda
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Select license:	Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

Academic metadata

Theses Type:	Doktorska disertacija
Academic Expertise :	Prirodno-matematičke nauke
Academic Title:	doktor nauka - hemijske nauke
University:	Univerzitet Crne Gore
Faculty:	Institut za interdisciplinarne i multidisciplinarne studije

Other Theses Metadata

Title translated:	Sinteza, fizičko-hemijska karakterizacija i procjena potencijalne biološke aktivnosti novosintetizovanih kompleksnih jedinjenja na bazi pirazola i amoksicilina
Format:	PDF/A (listova)
Abstract:	Pyrazole and its derivatives, among various other proven applications, present an important medical potential with numerous pharmacological activities. The limited number of safe and effective pharmacologically active substances indicates the need for the formation of new, safer, more efficient and effective solutions, i.e. active substances. Pyrazole derivatives are utilized as versatile ligands for synthesizing mono, bi, or polynuclear metal complexes. The role of pyrazolyl ligand depends on its oxidation state. Various possibilities for substitution at the pyrazole ring significantly enhance the diversity of coordination modes of pyrazole derivatives. Additionally, as one of the most commonly used antibiotics, amoxicillin, was presented a part of this research. During the research, numerous attempts of creating amoxicillin complexes have been conducted, with interesting results. With the current absence of overall data or already-existent pharmacological activity, ligands that have been the focus of this thesis are: 5-(4-bromophenyl)-3-methyl-1H-pyrazole, 4-methylpyrazole and 3-amino-4,5-dihydro-1-phenyl-1H-pyrazole and amoxicillin trihydrate. Other than the four previously mentioned ligands, the results of the attempts of syntheses with 2-(3-Aminophenyl)-5-methyl-2,4-dihydro-pyrazol-3-one hydrochloride are presented. The crystal and molecular structure of the synthesized complexes were determined by different combinations of techniques such are X-ray powder diffraction, C H N analyses, FTIR spectroscopy and single-crystal X-ray structure analysis. Since for further application of the selected compounds, more assays were conducted for the initial estimation of their potential, with emphasis on biological activity.
Authors Key words:	Pyrazole derivatives, complexes, amoxicillin, crystal structures, antioxidative capacity, in vitro assays
Language:	English

Abstract:

Pyrazole and its derivatives, among various other proven applications, present an important medical potential with numerous pharmacological activities. The limited number of safe and effective pharmacologically active substances indicates the need for the formation of new, safer, more efficient and effective solutions, i.e. active substances. Pyrazole derivatives are utilized as versatile ligands for synthesizing mono, bi, or polynuclear metal complexes. The role of pyrazolyl ligand depends on its oxidation state. Various possibilities for substitution at the pyrazole ring significantly enhance the diversity of coordination modes of pyrazole derivatives. Additionally, as one of the most commonly used antibiotics, amoxicillin, was presented a part of this research. During the research, numerous attempts of creating amoxicillin complexes have been conducted, with interesting results. With the current absence of overall data or already-existent pharmacological activity, ligands that have been the focus of this thesis are: 5-(4-bromophenyl)-3-methyl-1H-pyrazole, 4-methylpyrazole and 3-amino-4,5-dihydro-1-phenyl-1H-pyrazole and amoxicillin trihydrate. Other than the four previously mentioned ligands, the results of the attempts of syntheses with 2-(3-Aminophenyl)-5-methyl-2,4-dihydro-pyrazol-3-one hydrochloride are presented. The crystal and molecular structure of the synthesized complexes were determined by different combinations of techniques such are X-ray powder diffraction, C H N analyses, FTIR spectroscopy and single-crystal X-ray structure analysis. Since for further application of the selected compounds, more assays were conducted for the initial estimation of their potential, with emphasis on biological activity.